Fresh analysis indicates that patients who come off blockbuster slimming jabs like Wegovy and Mounjaro can put back on lost weight at a significantly accelerated pace than those who stop traditional diet and exercise programs.
Findings released in a prominent medical journal demonstrates that while obese people frequently drop about a fifth of their body weight while using the jabs, the mass is regained at an estimated rate of 0.8 kg per month upon discontinuation.
"Users buying such medications should be cognizant of the danger of quick rebound weight gain when the therapy is stopped," cautioned lead investigator Dr. Susan Jebb.
That rate of regain suggests a return to original mass in about a year and a half.
Comparing Approaches
The study, which reviewed dozens of trials involving thousands of patients, contrasted the results of GLP-1 agonists with conventional dieting.
The team point out that people who shed pounds through lifestyle changes alone typically experience a slower creep back—perhaps 0.1 kg a month—post-intervention.
Understanding the Fast Regain
Nutrition scientists suggest the way of the drugs is key to understanding the accelerated regain.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Long-term administration of the hormone concentrations far above than the body's typical production might result in the body to produce less of its endogenous hormone, and may also lessen sensitivity to its actions," noted Dr. Adam Collins, a dietetics researcher.
"Discontinuation of this GLP-1 'fix' means appetite is unsuppressed, making excessive eating a significant risk."
A Chronic Issue?
Medical guidelines recommend the injections for people with weight-linked medical conditions, accompanied by recommended lifestyle changes.
A number of clinicians argue that, given the high risk of relapse, the therapy might need to be life-long.
This opinion is supported by drug manufacturers, who say that the findings "emphasize the persistent nature of excess weight," akin to managing conditions like high blood pressure.
User Accounts
Individuals who have discontinued the jabs report a powerful return of cravings.
"It was like a trigger activating and I was suddenly extremely hungry," described a patient.
This difficulty is worsened if users have not developed permanent dietary or behavioural changes during therapy.
Widespread Interest
Figures suggest that millions of adults in the UK have used weight-loss jabs in the past year, with desire remaining high.
- Adoption is higher among women compared to males.
- The middle-aged age group shows the greatest level of interest.
- A large proportion access the medications through private prescriptions rather than the NHS.
In conclusion, clinicians stress that while these medications are powerful agents for shedding pounds, they are not a standalone cure and lasting health benefits likely depends on combined behavioural support.
